Errors during Replication. DNA replication is a highly accurate process, but mistakes can occasionally occur as when a DNA polymerase inserts a wrong base. Uncorrected mistakes may sometimes lead to serious consequences, such as cancer. Mutations: In this interactive, you can “edit” a DNA strand and cause a mutation.
DNA replication is a highly accurate process, but mistakes can occasionally occur, such as a DNA polymerase inserting a wrong base. Uncorrected mistakes may sometimes lead to serious consequences, such as cancer.
Replication errors can also involve insertions or deletions of nucleotide bases that occur during a process called strand slippage. Sometimes, a newly synthesized strand loops out a bit, resulting in the addition of an extra nucleotide base (Figure 3).
It is estimated that replicative eukaryotic DNA polymerases make errors approximately once every 104 – 105 nucleotides polymerized [58, 59]. Thus, each time a diploid mammalian cell replicates, at least 100,000 and up to 1,000,000 polymerase errors occur.
Also Know, why are errors in DNA replication so rare? The error in DNA replication is so rare because of proof reading activity, which maintains the fidelity of DNA replication. During DNA replication, the enzyme DNA polymerase III introduces complementary base pairs opposite to the bases of template strand.
What can cause mistakes in replication?
What is a thymine dimer?